The fourth round of the FA Cup will feature a Merseyside derby after Liverpool and Everton were the first two balls drawn out of the hat.
Anfield will host the standout tie, a week after the pair meet at the same ground in the league, while other highlights include non-league Kettering entertaining Fulham and Arsenal travelling to Cardiff.
Nottingham Forestís reward for beating Manchester City yesterday is a trip to bitter rivals Derby while Coca-Cola League One Hartlepool, who beat Premier League Stoke, host West Ham.
Torquay, the other non-league side left in the draw, were also drawn at home with Coventry the visitors.
The ties will be played on the weekend of January 24/25.
Liverpool v Everton
Southampton/Man Utd v Tottenham
Hull/Newcastle v Millwall/Crewe
Sunderland v Blyth Spartans/Blackburn
Hartlepool v West Ham
Leyton Orient/Sheff Utd v Charlton/Norwich
Cardiff City v Arsenal
Portsmouth/Bristol City v Histon/Swansea
Chelsea/Southend v Ipswich Town
Cheltenham/Doncaster v Aston Villa
West Brom/Peterborough v QPR/Burnley
Torquay Utd v Coventry City
Kettering Town v Fulham
Watford v Leicester/ Crystal Palace
Derby County v Nottm Forest
Birmingham/Wolves v Middlesbrough