I tried it once on my laptop, but it wouldn't see the keyboard and other things; it installed just fine however, but on a laptop, the keyboard compatibility is kinda important lol. I suspect it is probably because my primary laptop is a 12.1 C2D ultra-portable, and uses a proprietary reduced-key keyboard to fit it lol.
This was using a disc containing Snow Leopard, I can run you off a copy if you wanted to try it mate, but can't confirm whether it would work; it probably depends whether the OS likes the chipset and other hardware etc, I'd hazard a guess it would install and run, as to how useful the install would be is anyones guess lol. Any similar keyboard incompatibilities would be easier to resolve on a desktop.
I have never tried since, mainly because the only system I have with a c2d (or a compatible CPU for the case) is the ultra-portable - and I'm quite happy with Vista.